Neuroimaging Study Investigates Blast-Induced Traumatic Brain Injury

Visual perception tasks are performed in the scanner.

Visual perception tasks performed in the MRI scanner.

Dr. Thomas Meitzler, scientist at the U.S. Army Tank Automotive Research, Development and Engineering Center, and Dr. Joy Hirsch, professor at Columbia University and director of the Program for Imaging and Cognitive Sciences, join the Armed with Science podcast, Wed. Feb 3, 2010, at 2pm eastern. Listen live!

The number of Improvised Explosive Device (IED) casualties has increased tremendously, especially for Route Clearance Soldiers in Iraq and Afghanistan. Soldiers who are exposed to IED-associated blasts are often not aware of any resulting mild Traumatic Brain Injury (TBI) and return to duty without proper medical diagnosis and treatment.

The U.S. Army and Columbia University are collaborating on a project to develop a pre- and post-deployment functional Magnetic Resonance Imaging (fMRI) protocol that identifies a specific neural signature from blast-induced TBI in soldiers and provides vehicle intelligence. fMRI measures the changes in blood flow related to neural activity in the brain. Because fMRI’s are extremely sensitive to changes in the brain resulting from abnormal blood flow, fMRI research has been increasingly used for medical diagnosis of neurological diseases and as a guide treatment.

The proposed research will study fMRI scans to determine what areas of the brain are susceptible to damage, and measure the neural activity for TBI patients to determine the neural signatures related to IED-induced injury. The results of neuroimaging will measure the depth and extent of various levels of TBI, guide and monitor therapy, and prevent compounding injury by multiple blast exposures.

fMRI brain scans show which groups of neural circuits are being used for a specific tasks.Furthermore, blast intensity measurement research and fMRI studies can be linked together to measure the extent of TBI. The test data will be used to develop analytical math-based models to measure blast conditions and characterize injury. Using accelerometers and transducers, a sensor suite will be developed for military vehicle integration to supply vehicle intelligence.

The investigators are developing further test plans applying the new non-invasive techniques for study of human visual perception and neural processing of camouflage.

For more information, listen to the Armed with Science webcast #53 on Wednesday, February 3, 2010, at 2pm eastern.

  • Ryan

    This research is much needed, and may help establish what changes occur when a person suffers a TBI. I would hope that multiple regions’ function (dorsolateral prefontal being a strong candidate) are being tested (not just imaged).

  • Dr. Thomas Meitzler

    Ryan, in response to your question, the areas of the brain show up as active in the fMRI scan depend on the particular task the subject is being asked to complete at the time. The fMRI result will show any and all neural circuits engaged depending on the task.
    Tom

  • http://www.facebook.com/profile.php?id=1027996915 Eric Kothbauer

    I was a Husky operator in a route clearance patrol on my 2nd deployment to iraq, The IED’s we had this time around were much stronger than previously, Things like dual and triple arrayed EFP’s. Anyway, the vehicle I operated was struck by 5 separate blasts one of which gave me the headache I still retain almost a year later. I would love to be a test subject of yours if possible as I would like to get rid of the myriad of symptoms that plauge me. I think this study or the knowledge gleaned from it could help people alot more than the current treatments offered. For example; I was given a pamphlet by the army that defined TBI and that was it! After coming home and expressing my desire to be seen by a doctor for my injury, I had to wait four months to be treated at the VA. This was a full 9 months after my first blast injury! it is now nearly a year since my blast and I have recieved only light medications to treat the headache and trouble sleeping (Naproxen, Temazepam). No imaging was ever done on me, just guesses at to what might be affected and medication that does not work. I basically feel like I have a permanent hangover and feel like i am about to pass out, my memory is not the best anymore and I have found myself unable to remember why i am in the places I am in and how I got there. I apologise for the rant but could continue it for quite awhile. I will close by saying that not only is your research very important, but hopefully the findings you have unearthed get utilised. As far as Aug 2011 they most definately have not.
     

  • Anonymous

    Dear Mr. Kothbauer,

    I have some contact information for you. Could you please send an email to sciencedma.mil?

    Sincerely,
    Carla Voorhees

     

  • Anonymous

    Dear Mr. Kothbauer,

    I have some contact information for you. Could you please send an email to sciencedma.mil?

    Sincerely,
    Carla Voorhees

     

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